Hexinol Vs Retinol: Which Is Better?

As time goes by, the skin gradually loses its elasticity, wrinkles appear more and more. Moreover, the aging state at each age will be different, requiring women and men to understand what their skin condition is like and find the right care products. On average, people’s skin enters a new aging state every 10 years, so they are now increasingly using creams or serums that contain anti-aging ingredients like retinol or hexinol. However, between hexinol vs retinol which is the better ingredient to help save your skin?

To answer this question, we have researched, analyzed, and experienced to draw the fairest comment. In this article, we’ll give you the essential information about hexinol and retinol and compare them in a few key aspects to find out which is better for your skin. This article will provide the most concise and accurate information, so don’t miss it!

At A Glance

If you are someone who has a little interest in skincare and is especially interested in anti-aging and acne treatment for the skin, you must have heard of or even have a very solid knowledge of retinol. However, you also know recently it was discovered a new ingredient that has the same anti-aging effects as retinol is hexinol. Actually, retinol is being more appreciated by everyone including researchers and users for its effectiveness as compared to hexinol.

Hexinol Vs Retinol

First of all, retinol is a derivative of vitamin A and is part of the big term retinoids you often hear about. Retinol, after being applied to the skin, must undergo two conversions with enzymes available on the skin to form retinoic acid. From there, the retinoic acid will penetrate the skin and produce some rejuvenating effects on your skin. Retinol has been shown in numerous studies to be highly effective and is being included as an ingredient in many pharmaceutical and cosmetic products.

However, because hexinol is a new ingredient, there is very little research on it. Only a few studies from experts from RoC cosmetic companies have shown that hexinol has a very good effect on anti-inflammatory and anti-destructive collagen available in the skin, so it has anti-aging effects. This is just a one-sided study and has not been verified by other agencies, so there are many people who doubt its effectiveness.

After a quick look at their concept, how they work, and their effects on the skin, it seems that retinol has the upper hand due to more research. However, not everyone is suitable for using retinol as it has the potential to cause some skin irritation, and in this case, hexinol as a new anti-aging ingredient would be a better choice.

Furthermore, in order to know which is the better ingredient for you, you have to look at it in many ways. Below is a detailed and multi-faceted comparison of these two substances.

Hexinol Vs Retinol Comparison

Anti-Aging Effect

When looking for an answer to the question of which ingredient is better between the two ingredients, hexinol and retinol, most of you will focus on their anti-aging effects. However, each ingredient has a different anti-aging mechanism and brings different effects.

Hexinol Vs Retinol

As I mentioned above, retinol must become retinoic acid for the skin to be able to absorb it. Retinoic acid, when penetrated into the skin, will contribute to improving the stratum corneum, effectively increasing the musin and significantly reducing the melanin present in the epidermis. Therefore, it reduces and improves wrinkles. Retinol has been shown to have good anti-aging effects for people with photo-aging, has been FDA approved, and has been put into production and use. Studies have also shown that retinol significantly improves wrinkles within 6 months of use. However, many people only need to use retinol within 3 months to feel its effects.

On the other hand, hexinol is considered a technology and acts as an anti-inflammatory. The inflammatory reaction will destroy some of the collagen available in the skin, causing the skin to lose its elasticity and create wrinkles. Hexinol will help prevent inflammatory reactions from occurring and has been shown to greatly improve wrinkles under the eyes. Studies from RoC Skincare also show that hexinol will be effective after continuous use for 16 weeks. However, this is just a one-sided study, and the RoC also recommends combining hexinol with other ingredients for best results.

At this point, we realize that retinol is an ingredient that has been recognized by the FDA as having anti-aging properties while hexinol is just one-sided and unrecognized research. In addition, the time that retinol shows an effect on the skin is also slightly shorter than that of hexinol. Therefore, it can be concluded that retinol has a slight advantage in terms of anti-aging effects for the skin.

Acne Treatment Effect

Retinol has been shown to be effective in treating acne when combined with topical antibacterial therapies. Retinol is effective in reducing acne lesions and inhibiting microcomedone. However, compared to other generations of retinoids, retinol is not appreciated for its effectiveness in acne treatment, and to see acne results, retinol must be used in high concentrations. Anyway, this is still considered a clinically proven acne ingredient.

Hexinol Vs Retinol

About hexinol, if based on its mechanism, hexinol also has anti-acne effects on the skin. Since it is considered an anti-inflammatory, it inhibits inflammatory responses and somewhat reduces skin breakouts. However, this is just conjecture and does not have any clinical evidence. Also, people who have used RoC products containing hexinol have not seen any of its acne-fighting effects.

At this point, we can conclude that hexinol will be weaker than retinol in terms of acne treatment effectiveness. Although its mechanism can suppress the symptoms of dermatitis, hexinol has not been shown to be as effective as retinol.

Skin Pigmentation Improvement Effect

There is another aspect that also needs to be taken into account when comparing hexinol and retinol, which is the improvement of skin pigmentation, skin tone, and skin lightening.

Hexinol Vs Retinol

First of all, although not as effective in terms of improving skin pigmentation as vitamin C or glutathione, retinol has been shown to be able to even out skin tone and improve skin texture. It can treat freckles, pigment spots, dark spots, and scars when combined with AHAs. However, you have to use retinol continuously for a long time to see results on scars and pigment spots.

On the contrary, hexinol was concluded to have the ability to improve skin pigmentation. However, the mechanism by which it works to improve pigmentation has not been clearly demonstrated or explained. This is still a one-sided conclusion and not many people recognize the effectiveness of hexinol in improving skin pigmentation even those who have used this ingredient.

Therefore, in terms of even skin tone and skin pigmentation improvement, retinol is still appreciated by people. Although there is no immediate effect, retinol does provide positive results after a long time of use.

Safety Level

Compared to tretinoin which is also another generation of retinoids, retinol has significantly reduced irritation when used on the skin. However, it still causes some reactions such as skin redness or burning. Also, it is advised not to be used by pregnant mothers. If used in large amounts, retinol must be prescribed by a doctor.

Hexinol Vs Retinol

Hexinol is said to be a discovery that has less irritating anti-aging properties than retinol. Until now, hexinol has not been found to cause any side effects after use nor has any effect on your health. People who have used RoC products containing hexinol have also reported that it does not cause skin irritation, redness, or dryness. However, to be safe, pregnant women should still not use hexinol.

When it comes to safety, hexinol seems to be better than retinol because it does not cause any side effects on the skin and does not adversely affect the body.

Price Of The Product

Products containing retinol due to its anti-aging effects are also slightly more expensive than other moisturizers or serums. Also, retinol with a high percentage is not commonly used and must be prescribed by a doctor, so it is quite difficult to buy. Most products that contain a large percentage of retinol are in the pharmaceutical category.

Hexinol Vs Retinol

On the other hand, hexinol is also an anti-aging product, so it’s also a bit more expensive than normal products. Also, it is difficult to find another product containing hexinol other than RoC as this can be considered a unique finding of this company.

Therefore, because they are all in the category of substances with anti-aging properties, in terms of price, this is an inconclusive battle between hexinol and retinol.

Hexinol Vs Retinol: Which Is The Overall Winner?

After the most detailed comparison, retinol beats hexinol in many ways. Retinol is a powerful substance that has a huge effect on improving the texture of the skin.

However, it’s not that retinol seems to be more beneficial, it’s right for everyone. For some people, choosing hexinol may be a better choice.

In particular, hexinol will be the best choice for those who have never used skin care products containing strong active ingredients such as retinoids, BHA, or AHA. Although the results are slow and not noticeable, this will be the best option to help you avoid skin irritation, burning, and dryness. Besides, you also do not need to consult a dermatologist before using hexinol.

On the other hand, retinol will be suitable for those who have used strong skincare ingredients and want to see visible anti-aging results. However, it can cause some irritation to you, and you must consult a doctor if using it in high percentage. When using it as a serum or essence, you need to fully moisturize to avoid drying out your skin.

Best Hexinol Vs Retinol Products 

RoC Multi Correxion 5 in 1 Restoring/Anti Aging Facial Night Cream

RoC Multi Correxion 5 in 1 Restoring/Anti Aging Facial Night Cream with Hexinol, 1.7 Oz (Packaging...
  • WRINKLE TREATMENT FOR FACE & NECK: Enhance your skin's natural night-time repair & reduce key signs of aging in only 4 weeks. Wake up to rejuvenated, healthier-looking skin with a more even-looking tone.
  • GENTLE ENOUGH FOR DAILY USE: This non-greasy, non-comedogenic formula with glycerin uses our breakthrough Hexinol technology to improve dark spots & discolorations, firm & hydrate skin, visibly reduce fine lines & wrinkles & restore radiance.
  • ANTI-AGING FORMULAS: Whether you're looking for a solution for deep wrinkles, fine lines, dark circles, crow's feet, uneven skin tone or dry skin, we have an anti-aging formula that's right for you.

RoC Multi Correxion 5 in 1 Restoring/Anti Aging Facial Night Cream comes in a cream form with the application of Hexyl-R Complex technology, which is also the hexinol technology that we mentioned earlier. Besides hexinol, it also contains a lot of ingredients such as Isononyl Isononanoate and Butyrospermum Parkii (Shea) Butter that both moisturize and avoid the side effects that can occur when used with hexinol technology. Besides, this product also contains ascorbyl glucoside which is a derivative of vitamin C. Hexinol combined with ascorbyl glucoside is also a good combo to help increase collagen for the skin.

This stuff is suitable for those who want to anti-aging with gentle hexinol. However, its ingredients are quite moisturizing, although most of them are benign, using them a lot will clog pores and cause acne.

Paula’s Choice CLINICAL 1% Retinol Treatment Cream

Paula's Choice CLINICAL 1% Retinol Treatment Cream with Peptides, Vitamin C & Licorice Extract,...
  • DIMINISH THE APPEARANCE OF WRINKLES: This expert-level, high-strength formula absorbs quickly & delivers immediate powerful results. Antioxidant vitamins C &E paired with hydrating hyaluronic acid and skin-firming peptides help deliver advanced anti-aging results. PACKAGING MAY VARY.
  • Paula's Choice CLINICAL 1% Retinol Treatment with Peptides & Vitamin C is formulated to reduce the appearance of wrinkles as it refines pores and firms skin for a radiant, rejuvenated, more youthful appearance. This robust formula also helps prevent signs of aging and softens the look of post-acne marks.
  • Paula's Choice CLINICAL 1% Retinol is an ideal anti-aging serum for normal, combination, dry, & oily skin. Try mixing with 2-3 drops of Paula's Choice Moisture Renewal Oil Booster. Use at night with Paula's Choice cleanser, toner, exfoliator & night cream

This is a product from Paula’s Choice that contains 1% retinol along with peptides and vitamin C. Paula’s Choice CLINICAL 1% Retinol Treatment Cream not only has anti-aging capabilities thanks to retinol but also provides peptides to help reduce skin irritation when using retinol. This product also contains substances that help soften the skin and restore the skin. Also, most of the ingredients in this product are quite benign and unlikely to cause skin irritation except for retinol.

In addition, Paula’s Choice CLINICAL 1% Retinol Treatment Cream has packaging made of a sealed plastic bottle that sunlight cannot penetrate, so it helps to preserve the retinol well. Moreover, the pump form also helps minimize the ability of retinol to be affected by the air, so the retinol will be better preserved and work better for a longer time.


This article has provided complete and accurate information to help you figure out what is the best ingredient between hexinol vs retinol. Hope you guys can know what the most suitable ingredient for you in the skincare process is to get the youthful and healthy skin you want.

Also, if you have any questions regarding hexinol and retinol or questions about related products, don’t hesitate to comment below. We are always available and happy to answer any of your questions.

Last but not least, don’t forget to follow this website for more useful and accurate information!

Read Also:
Tightenyl And Proper Skin Care!
Top 13 Best Thrive Cosmetics Lawsuit Reviews & Comparison

Leave a Comment